Endocrine Abstracts

Ghrelin as well as leptin are involved into regulation of food intake, development of obesity, diabetes (DM I, DM II) and inflammation. However, in spite of many experiments, the correlation between their effects are not fully established. As a part of study dealing with the interaction of ghrelin and leptin in metabolic disorders the present study was carried out to assess the effect of statin, DMI, DMII on the ghrelin and leptin plasma levels in lean and obese piglets. Anima...

Ghrelin is protein hormone originally isolated from the stomach and it is the endogenous ligand for the growth hormone secretagogue receptor (GSH-R 1a). It is well established that ghrelin plays roles in appetite regulation, gut function, metabolic disorders and inflammation. Ghrelin and its receptor is expressed in brain and peripheral tissues sensitive to inflammation such as heart and spleen. As a part of study dealing with the role of ghrelin in the development of inflamma...